Product Pipeline Pipeline

Our Pipeline

Progenics has a pipeline that includes products in pre-clinical through late-stage development. We are focused on critical unmet diagnostic and therapeutic needs of prostate cancer patients.


PSMA Targeted Oncology

  • 1404
    Tc-99m Diagnostic Imaging Agent

    1404 is a technetium-99m labeled small molecule which binds PSMA and is used as an imaging agent to diagnose and detect localized prostate cancer as well as soft tissue and bone metastases. We have completed a global multi-centered Phase 2 trial assessing the diagnostic accuracy of 1404 imaging in men with high-risk prostate cancer and a multi-center, open-label Phase 3 trial is ongoing to determine the sensitivity and specificity of 1404 to correctly identify whether or not patients have clinically significant prostate cancer (generally, Gleason score >3+4). MORE>

  • PyL
    F-18 Diagnostic Imaging Agent

    PyL (also known as [18F]DCFPyL) is a clinical-stage, fluorinated PSMA-targeted Positron Emission Topography (PET) imaging agent for prostate cancer that was discovered and developed at the Center for Translational Molecular Imaging at the Johns Hopkins University School of Medicine. A proof-of-concept study published in the April 2015 issue of the Journal of Molecular Imaging and Biology showed that the uptake of PyL is high in sites of putative metastatic lesions and primary tumors, suggesting the potential for high sensitivity in detecting prostate cancer. A phase 2/3 trial commenced in December 2016 to assess the diagnostic performance of PyL PET/CT imaging to detect prostate cancer in patients with recurrent and/or metastatic disease. MORE>

  • 1095
    I-131 Small Molecule Theranostic

    1095 is a PSMA-targeted Iodine-131 labeled small molecule that is designed to deliver a dose of beta radiation directly to prostate cancer cells with minimal impact on the surrounding healthy tissues. In collaboration with Memorial Sloan-Kettering Cancer Center, an Investigational New Drug (“IND”) application has been filed in the U.S. and a Phase 1 trial has been initiated. MORE>

  • PSMA TTC

    PSMA TTC is a thorium-227 labeled PSMA-targeted antibody therapeutic. The PSMA TTC is designed to deliver a dose of alpha radiation directly to prostate cancer cells with minimal impact on the surrounding healthy tissues. In April 2016, we granted Bayer exclusive worldwide rights to develop and commercialize products using our PSMA antibody technology in combination with Bayer’s alpha-emitting radionuclides.


Oncology

  • Azedra®
    I-131 Theranostic (MIBG)

    SPA

    AZEDRA is a radiotherapeutic product candidate in development as a treatment for malignant and/or recurrent pheochromocytoma and paraganglioma, rare tumors found in the adrenal glands and outside of the adrenal glands, respectively. AZEDRA has been granted Breakthrough Therapy and Orphan Drug designations, as well as Fast Track status in the U.S. Under a SPA agreement with the FDA, a Phase 2 registrational trial has been completed in patients with malignant and/or recurrent pheochromocytoma and paraganglioma; there is currently no FDA-approved therapy for the treatment of these ultra-orphan diseases. MORE>


Oncology Supportive Care

  • RELISTOR® SC

    RELISTOR® subcutaneous injection, a small-molecule mu-opioid receptor antagonist, is approved in the United States for the treatment of opioid induced constipation in adult patients with chronic non-cancer pain. Progenics has licensed Relistor® to Salix Pharmaceuticals, Inc., a wholly owned subsidiary of Valeant Pharmaceuticals International, Inc. in markets worldwide.

  • RELISTOR® Oral

    RELISTOR® Tablets (methylnaltrexone bromide) is approved in the U.S. for the treatment of opioid-induced constipation (OIC) in adults with chronic non-cancer pain. Progenics has licensed Relistor® to Salix Pharmaceuticals, Inc., a wholly owned subsidiary of Valeant Pharmaceuticals International, Inc. in markets worldwide.

  • RELISTOR® SC (AI-Japan)


Partnered Programs

  • PRO 140

    PRO 140 is a humanized anti-CCR5 monoclonal antibody created at Progenics and now developed by CytoDyn, Inc. PRO 140 is in Phase 3 testing as a treatment for human immunodeficiency virus (HIV) infection.  MORE>